- Homer Simpson: Main character and father of the Simpson family.
- Marge Simpson: Homer's wife and matriarch of the Simpson family.
- Bart Simpson: Homer and Marge's oldest child and troublemaker.
- Lisa Simpson: Homer and Marge's middle child and intellectual.
- Maggie Simpson: Homer and Marge's youngest child, who remains perpetually in infancy.
- Grandpa Abe Simpson: Homer's father and retiree living in a nursing home.
- Patty and Selma Bouvier: Marge's sisters and identical twins.
- Ned Flanders: The Simpsons' next-door neighbor and a devout Christian.
- Milhouse Van Houten: Bart's best friend.
- Nelson Muntz: Class bully who often picks on Bart.
- Ralph Wiggum: Dimwitted son of Springfield Police Chief Wiggum.
- Seymour Skinner: Principal of Springfield Elementary School where Bart attends.
- Mr. Burns: Wealthy owner of the Springfield Nuclear Power Plant where Homer works.
- Moe Szyslak: Owner of Moe's Tavern, where Homer and his friends hang out.
- Apu Nahasapeemapetilon: Kwik-E-Mart owner who speaks with an Indian accent.
- Waylon Smithers: Mr. Burns' sycophantic personal assistant.
- Professor Frink: Eccentric scientist who works at Springfield Nuclear Power Plant.