* Charlie Murphy (1959-2017), actor and comedian
* Vernice "Shirley" Murphy (born c. 1960), musician and actress
* Rosalind Murphy (born c. 1961), screenwriter
* Anya Murphy (born c. 1962), actress and singer
* Craig Murphy (born c. 1963), basketball player and actor
* Paul Murphy (born c. 1964), actor
* Dwayne Mitchell (born c. 1966), actor
* Terrell Murphy (born c. 1972), actor and comedian
* Eric Murphy (born c. 1989), actor and musician
Eddie Murphy is the oldest of the ten children born to Charles Edward Murphy and Lillian Lynch.