* Cody Martin: Cody is Zack's 12-year-old twin brother. He is the more responsible and intelligent of the two, but he can still be mischievous at times. He is often seen with his twin brother, Zack, and his best friend, Moseby.
* London Tipton: London is a 15-year-old girl who is the daughter of a hotel magnate. She is rich, spoiled, and often acts like a diva. She is often seen with her friends, Zack and Cody.
* Maddie Fitzpatrick: Maddie is a 16-year-old girl who works as a candy counter girl at the Tipton Hotel. She is kind, caring, and often the voice of reason for Zack and Cody. She is often seen with her boyfriend, Zack.
* Esteban Ramirez: Esteban is the head of the maintenance staff at the Tipton Hotel. He is often seen helping Zack and Cody out of trouble. He is often seen with his co-worker, Arwin.
* Arwin Hawkhauser: Arwin works at the Tipton Hotel as a bellhop and is friends with Esteban.