However, some well-known comedy actresses who haven't appeared alongside him in a major role include:
* Melissa McCarthy: Known for her physical comedy and broad characters, she's never shared the screen with Pitt in a major production.
* Amy Poehler: Another comedic powerhouse, Poehler has never worked with Pitt in a film or television project.
* Tina Fey: A master of witty dialogue and sharp satire, Fey hasn't collaborated with Pitt on any known projects.
* Kristen Wiig: With her unique brand of quirky humor, Wiig hasn't yet had a chance to star opposite Pitt.
Of course, there are many other talented comedy actresses who could fit this bill. It's a fun thought experiment to consider who would be a great pairing with Brad Pitt in a comedic role!