- Bruce Reitherman as Mowgli
- Phil Harris as Baloo
- Louis Prima as King Louie
- Sebastian Cabot as Bagheera
- George Sanders as Shere Khan
- Sterling Holloway as Kaa
- J. Pat O'Malley as Colonel Hathi
- Verna Felton as Winifred
- Junius Matthews as Flunkey
- Chad Stuart and Jeremy Clyde as the vultures - Buzzy, Flaps, Ziggy, Dizzy, and Buzzie
2016 live-action adaptation:
- Neel Sethi as Mowgli
- Bill Murray as Baloo
- Christopher Walken as King Louie
- Ben Kingsley as Bagheera
- Idris Elba as Shere Khan
- Scarlett Johansson as Kaa
- Giancarlo Esposito as Akela
- Lupita Nyong'o as Raksha
- Naomie Harris as Nisha
- Sam Raimi as the giant bee
- Garry Shandling as Ikki