Click the "S" icon next to the audio file to be corrected or manipulated, for example "Lead Vox 1." This icon engages the solo function, which mutes all other audio. This way you can listen to the audio in isolation.
Open the effects menu and select "Auto Tune." In some programs, such as Mixcraft and Pro Tools, Auto Tune is located under the "Plugins" menu.
Click "Play" so you can hear the effect of Auto Tune in real-time.
Enter the key of the song. This gives Auto Tune a set of pitch parameters so it knows which pitches should and should not be in the vocal.
Click "Input Type" and make a selection. For a subtle corrective Auto Tune effect, select the option that most closely matches the vocal register of the vocal audio, for example "Tenor." For an artificial, robotic sound similar to that used by T-Pain in "Take Your Shirt Off" select an option that doesn't match the vocal recording. This effectively "confuses" Auto Tune into moving notes out of the original register. So a low note is switched to a high register if it is out of tune.
Adjust the "Retune Speed" dial. This governs how quickly a bum note becomes an in-tune note. For an instant correction, dial it to zero. This creates a rapid and distinctly "computerized" sound. It is how the unusual vocal sound on Cher's "Believe" was created. For a more natural and subtle effect, set it somewhere between fifty and seventy percent.
Adjust the "Tracking" parameter. This controls the pitch range threshold. The two extremes of this parameter are labelled as "Relaxed" and "Choosy." The former sets Auto Tune to only correct obviously out-of-tune notes and the latter configures Auto Tune to jump on anything that deviates even a tiny amount from perfect-pitch.
Hit "Save" when you create an effect that suits your preferences.