- Gibson Trini Lopez: Grohl's main live electric guitar.
- Gibson ES-335: Used on Nirvana's "In Utero" and Foo Fighters' "The Colour and the Shape" albums.
- Fender Telecaster: Used on Foo Fighters' "There Is Nothing Left to Lose" and "One by One" albums.
- Gibson SG: Used on Foo Fighters' "Echoes, Silence, Patience & Grace" album.
- Gretsch White Falcon: Used on Foo Fighters' "Wasting Light" album.
- Gibson Flying V: Used on Foo Fighters' "Sonic Highways" album.
Acoustic Guitars
- Martin D-28: Grohl's main acoustic guitar.
- Gibson J-45: Used on Nirvana's "Unplugged in New York" album.
- Taylor 814ce: Used on Foo Fighters' "Concrete and Gold" album.