1. Piano: Ray Charles himself plays the piano throughout the song, providing the main melody and chords. His distinctive piano playing style, characterized by soulful improvisation and rhythmic syncopation, is one of the highlights of the track.
2. Electric Bass: An electric bass guitar provides the low-end groove and rhythm section along with the drums.
3. Drums: A drum kit, including snare, bass drum, cymbals, and hi-hats, delivers the rhythmic foundation and keeps the song moving forward.
4. Trumpet: A trumpet is used for the song's iconic horn riff, which introduces the song and recurs throughout.
5. Saxophone: A saxophone adds layers of soulful harmony and fills during the chorus sections.
6. Guitar: A guitar, likely an electric guitar, plays a supporting role, providing subtle chords and fills that complement the piano.
These instruments, when combined, create the dynamic and energetic arrangement of "Hit the Road Jack," blending jazz, blues, and R&B influences that made it a timeless hit in Ray Charles' career.