* Piano: He has mentioned playing the piano in interviews and has even performed on it in some of his roles.
* Guitar: He has been seen playing the guitar in some of his television appearances, and has even performed with a band.
* Drums: He has shown off his drumming skills in a few appearances.
* Ukulele: He has a ukulele in his home and has shown interest in learning it.
While he is not a professional musician, Neil Patrick Harris seems to enjoy playing various instruments for fun and has even incorporated them into his work.