* The dangers of hubris: The Elric brothers' attempt to use alchemy to revive their mother leads to their own mutilation, highlighting the potential dangers of unchecked ambition and pursuing knowledge without understanding its full implications.
* The search for truth: The series explores the nature of truth and how it can be distorted or manipulated, especially within the context of the military and the State Alchemist program.
* The importance of human connection and empathy: The series emphasizes the value of human relationships and how they can help individuals navigate the complexities of their own experiences. This is evident in the strong bonds between the Elric brothers, as well as the various relationships they forge throughout their journey.
* The ethical implications of scientific advancement: Fullmetal Alchemist grapples with the ethical dilemmas posed by powerful technologies, like alchemy, and the potential for abuse. It encourages the audience to consider the responsibility that comes with knowledge and its applications.
Ultimately, the series suggests that while the pursuit of knowledge is valuable, it must be balanced with wisdom, empathy, and a deep understanding of its potential impact on the world and those around us.