* Matt Damon as Rudy Baylor, a young and idealistic lawyer.
* Danny DeVito as Deck Shifflet, a cynical and experienced lawyer who mentors Rudy.
* Mickey Rourke as Leo F. Drummond, the ruthless CEO of a powerful insurance company.
* Claire Danes as Kelly Riker, a young woman with a terminal illness who Rudy represents.
* Jon Voight as Judge Harry Truman, a corrupt and powerful judge who works with Drummond.
* Mary Kay Place as Bruiser Stone, a tough and seasoned investigator who helps Rudy.
* Roy Scheider as the head of the insurance company's legal department.
* Teresa Wright as Kelly's mother.
* Alec Baldwin as a doctor who testifies against the insurance company.
These actors play pivotal roles in the story, shaping the narrative and driving the conflict.