* Eddie Hazel - American funk guitarist, songwriter, and producer, best known as a member of the funk band Parliament-Funkadelic.
* Eddie Cochran - American rock and roll guitarist, songwriter, and singer.
* Eddie Lang - American jazz guitarist and banjoist.
* Eddie Durham - American jazz guitarist, violinist, and composer.
* Eddie Boyd - American blues guitarist, singer, and songwriter.
* Eddie Cleanhead Vinson - American blues saxophonist, singer, and songwriter, also known for his guitar playing.
* Eddie Kirkland - American blues guitarist and singer.
* Eddie Taylor - American blues guitarist, singer, and songwriter.
* Eddie "Guitar Slim" Jones - American blues guitarist and singer.