- Woodrow Parfrey: Parfrey played the character "Sam Noonan," a blacksmith and occasional deputy in Dodge City. He appeared in over 50 episodes of the series.
- Buck Taylor: Taylor portrayed "Newly O'Brien," a ranch hand and good friend of Matt Dillon. He appeared in over 250 episodes of the series.
- Dennis Weaver: Weaver played "Chester Goode," a deputy in Dodge City. He appeared in over 290 episodes of the series.
- James Arness: Arness played the lead role of "Matt Dillon," the U.S. Marshal of Dodge City. He appeared in all 635 episodes of the series.