* "Saturday Night Live" (1990-1994): She was a cast member on SNL for four seasons and is remembered for her recurring character, "Pat," a androgynous character who challenged gender norms and stereotypes.
* "God Said Ha!": Her one-woman show, which she wrote and performed, was a critical and commercial success, earning her a Drama Desk Award. It explored her personal experiences with religion, faith, and spirituality.
* "Shrill" (2019-2021): She played Gail, the mother of the protagonist, on the Hulu comedy series, based on Lindy West's book.
While Sweeney has also worked on other TV shows, films, and stage productions, these are the projects she is most recognized for.