Movies:
* The Wedding Singer (1998): The song "Personal Jesus" is featured in the film.
* The Lost Boys (1987): "Never Let Me Down Again" plays during a crucial scene.
* The Crow (1994): "Enjoy the Silence" is prominently used.
* Sliver (1993): "I Feel You" appears in the film.
* Donnie Darko (2001): "Enjoy the Silence" is heard on the soundtrack.
* American Psycho (2000): "Personal Jesus" appears in the film.
* A Scanner Darkly (2006): "Walking in My Shoes" plays on the soundtrack.
* Control (2007): A biopic about Depeche Mode's early years, though the band themselves don't appear.
* The Social Network (2010): "Never Let Me Down Again" is featured.
Television:
* The Simpsons: Depeche Mode has had a number of appearances on the show, including a performance of "Personal Jesus" (and Dave Gahan's voice even provided a vocal sample for a character).
* South Park: The band has been featured in a few episodes, most notably "Butters' Very Own Episode."
* American Dad: The band has been featured in an episode, "The Most Dangerous Game."
* The X-Files: "Enjoy the Silence" appeared in an episode.
* Grey's Anatomy: "Never Let Me Down Again" is featured in an episode.
* The O.C.: "Personal Jesus" played in an episode.
* Sex and the City: "Enjoy the Silence" was featured in an episode.
* Ugly Betty: "Personal Jesus" played in an episode.
* Dexter: "Personal Jesus" was featured in the show's season 6 finale.
Video Games:
* Grand Theft Auto: San Andreas: "Personal Jesus" is featured on the game's in-game radio station.
* Grand Theft Auto V: "Personal Jesus" is featured in the game.
* Guitar Hero World Tour: The song "Personal Jesus" is playable in this video game.
This is by no means an exhaustive list, but it gives you an idea of the broad range of projects Depeche Mode's music has been featured in. Their songs have become integral parts of many iconic moments in film and television, solidifying their legacy as a cultural force.