1. Thanos: Thanos, the Mad Titan, wields immense power and possesses the Infinity Gauntlet, capable of manipulating reality on an unimaginable scale.
2. The Beyonder: A cosmic entity of immense power, beyond the understanding of mortal minds, has the ability to manipulate and reshape reality at will.
3. Galactus: The Devourer of Worlds possesses immense cosmic power, capable of consuming entire planets and bending the fabric of reality to his will.
4. Molecule Man: With the ability to manipulate matter and energy on a fundamental level, Molecule Man can potentially disintegrate Deadpool's molecular structure.
5. Franklin Richards: The son of Mr. Fantastic and the Invisible Woman, Franklin Richards has incredible reality-warping powers and could theoretically alter reality to eliminate Deadpool.
6. The One-Above-All: As a supreme being, The One-Above-All has ultimate control over the Marvel Universe and could potentially wipe out Deadpool's existence.
7. The Sentry: The Sentry possesses vast superhuman abilities, including molecular manipulation, which could potentially allow him to disintegrate Deadpool.
8. Scarlet Witch: With her reality-altering powers, Scarlet Witch could potentially alter reality to erase Deadpool's existence or transform him into a non-threatening form.
9. Cosmic Cube Wielders: Cosmic Cubes, such as the Tesseract, grant reality-warping abilities, and in the hands of powerful individuals, they could potentially erase Deadpool from existence.
10. Deadpool himself: Deadpool's regenerative abilities have limits. If subjected to extreme forces, such as complete incineration or having all of his molecules scattered across the universe, it's possible that even he could be destroyed.