- Will Smith: Smith has played many memorable uncles in movies, such as Uncle Phil in "The Fresh Prince of Bel-Air" and Uncle Ben in "Spider-Man: Homecoming".
- Tommy Lee Jones: Jones has often played tough but wise uncles in movies, such as Agent K in the "Men in Black" series and Sheriff Ed Tom Bell in "No Country for Old Men".
- John Goodman: Goodman has played a variety of uncles in movies, from the lovable and bumbling Uncle Rico in "Napoleon Dynamite" to the villainous Victor Drago in "Creed".
- Samuel L. Jackson: Jackson has played many different types of uncles in movies, from the stern and serious Uncle Frank in "Do the Right Thing" to the more lighthearted and comedic Uncle Earl in "Django Unchained".
- Robin Williams: Williams was known for his ability to play a wide range of characters, including uncles. Some of his most memorable uncle roles include Genie in "Aladdin" and Teddy Roosevelt in "Night at the Museum".