What spin-off of Strokes starred Molly Ringwald and George Clooney at various times?

The spin-off of "The Facts of Life" starring Molly Ringwald was called "The Facts of Life: The Next Generation". George Clooney did not appear in this spin-off.

You may be thinking of "The Facts of Life" itself, which did feature both Molly Ringwald and George Clooney in separate guest-starring roles.

* Molly Ringwald played Molly in the episode "Molly's Choice" (1985)

* George Clooney played George in the episode "The Lottery Ticket" (1985)

However, neither of them were recurring characters on the show.