* Prison Break (2005-2009, 2017) as Dr. Sara Tancredi, a role that launched her to fame.
* The Walking Dead (2010-2014, 2018) as Lori Grimes, the wife of Rick Grimes and mother of Carl Grimes.
While she has starred in other TV shows and films, these two roles are the ones that solidified her career and for which she is most recognized by audiences.