Movies:
* The Tournament (2009) as Blair
* The Final Destination (2009) as Lori Milligan
* The Butterfly Effect 3: Revelations (2009) as Kiley
* The Messengers (2007) as Jess
* The Extreme Team (2003) as Erin
* Going Overboard (2001) as Cindy
* The Rage: Carrie 2 (1999) as Rachel Lang
* The Faculty (1998) as Delilah Profitt
* Cube 2: Hypercube (2002) as Rave
* The Last Time I Saw You (2015) as Sarah
* The Recall (2017) as Carly
* The Ninth Life of Louis Drax (2016) as Natalie
Television:
* The Listener (2009-2014) as Olivia "Liv" Sweeney
* The L Word (2004-2009) as Shane McCutcheon
* The Secret Life of the American Teenager (2008-2013) as Amy Juergens
* Tru Calling (2003-2005) as Lindsay Walker
* Mutant X (2001-2004) as Emma DeLauro
* The Twilight Zone (2002) as Jenna
* The Chris Isaak Show (2001-2004) as Susan
* The 4400 (2004-2007) as Isabelle
* The Dead Zone (2002-2007) as Sarah Bracknell
* The Tomorrow People (2013-2014) as Astrid Finch
* The 100 (2014-2020) as Roan
* The Expanse (2015-2022) as Naomi Nagata
* The Haunting of Hill House (2018) as Theodora "Theo" Crain
This is not an exhaustive list, but it includes some of her most notable roles. Lauren Lee Smith is a versatile actress who has appeared in a wide variety of projects.