Films:
* The Old Mill Pond (1967): This was her first major film role, where she played the role of a fortune teller.
* The Sterile Cuckoo (1969): This film earned her an Academy Award nomination for Best Supporting Actress. She played the eccentric landlady, Mrs. Peck.
* The Devil and Miss Jones (1941): Although not released until 1941, she appeared in this film as a young actress. It was her first screen credit.
* The Daydreamer (1966): She played a supporting role in this fantasy comedy.
* The Last of Sheila (1973): A critically acclaimed mystery film featuring Ghostley in a supporting role.
* The Devil's Advocate (1997): She had a small role as a nun in this legal thriller.
* The Addams Family (1991): She voiced Granny in this popular comedy.
* The Addams Family Values (1993): She reprised her role as Granny in this sequel.
Television Shows:
* The Andy Griffith Show (1962-1968): Ghostley appeared in multiple episodes as the eccentric and gossipy Miss Minnie Cooper.
* Bewitched (1964-1972): She played the nosy neighbor, Esmeralda, in several episodes.
* The Ghost & Mrs. Muir (1968-1970): She had a recurring role as the gossipy housekeeper, Mrs. Edna Pratt.
* The Love Boat (1977-1986): Ghostley guest-starred in multiple episodes.
* The Golden Girls (1985-1992): She appeared in several episodes as various characters.
* Designing Women (1986-1993): Ghostley had a recurring role as Suzanne Sugarbaker's mother, Bernice.
* Murder, She Wrote (1984-1996): She guest-starred in multiple episodes.
* Touched by an Angel (1994-2003): She played a variety of characters throughout the show.
* The Nanny (1993-1999): She appeared in several episodes as Fran's mother, Sylvia Fine.
This is not an exhaustive list, as Ghostley's career was extensive. She also appeared in various stage productions and had a long and successful voice acting career.