While Leonardo DiCaprio and Paul Rudd are not in the movie, the cast does include:
* Radha Blank as Radha
* Peter Kim as Osmany
* Oshun Jones as Niecy
* Reed Birney as David
* Uzo Aduba as Nona
* Olivia Thirlby as Lacey
* Talia Balsam as Regina
* and, yes, Jesse Bradford and John Leguizamo.
It's possible you're mixing up the actors or are thinking of a different movie.