* Shannen Doherty as Prue Halliwell
* Holly Marie Combs as Piper Halliwell
* Alyssa Milano as Phoebe Halliwell
* Rose McGowan as Paige Matthews (seasons 4–8)
* Dorian Gregory as Darryl Morris (seasons 1–7)
* Brian Krause as Leo Wyatt (seasons 1–7)
* Julian McMahon as Cole Turner (seasons 3–5)
Recurring cast
* Victor Webster as Coop (seasons 7–8)
* Kerr Smith as Kyle Brody (season 2)
* David Reivers as Inspector Rodriguez (season 3)
* Eric Dane as Jason Dean (season 4)
* James Read as Victor Bennett (seasons 1–3, 8)
* Finola Hughes as Patty Halliwell (season 3)
* Billy Drago as Barbas (seasons 2–3)
* Balthazar Getty as Richard Montana (season 5)
* Kaley Cuoco as Billie Jenkins (season 8)
* Amy Acker as Christy Jenkins (season 8)
* Charisma Carpenter as Kyra (season 8)