* The Prince of Tides (1991) as Savannah Beaufort
* The Hand that Rocks the Cradle (1992) as Peyton Flanders
* Night Watch (1997) as Jessica Nolan
* The Negotiator (1998) as Maggie
* Ride with the Devil (1999) as Sue Lee Shelley
* The Bone Collector (1999) as Amelia Donaghy
* Liberty Heights (1999) as Dubbie Halpern
* The Weather Man (2005) as Noreen
* The Savages (2007) as Wendy Savage
* The Great Debaters (2007) as Samantha Booke
* Fur: An Imaginary Portrait of Diane Arbus (2006) as Diane Arbus
* Perfect Stranger (2007) as Grace Clayton
* The Prince of Tides (2012) as Savannah Beaufort
TV series
* ER (1994-1995) as Dr. Kerry Weaver
* The West Wing (2000-2006) as C.J. Cregg
* Kidnapped (2006-2007) as Dana Banks
* Law & Order: Criminal Intent (2007-2011) as Detective Alexandra Eames
* The Good Wife (2011-2016) as Alicia Florrick
* The Newsroom (2012-2014) as MacKenzie McHale
* The Good Fight (2017-present) as Diane Lockhart