* The Prince of Tides (1991) as Lila Newbury
* The Landlady (1992) as Nancy Anderson
* The Crush (1993) as Adrian Forrester
* Shallow Grave (1994) as Juliet Miller
* Moll Flanders (1996) as Moll Flanders
* In & Out (1997) as Cameron Drake
* The Governess (1998) as Rosina da Silva
* The Next Best Thing (2000) as Abbie Reynolds
* Shallow Hal (2001) as Rosemary Shanowski
* Maid in Manhattan (2002) as Marisa Ventura
* Stuck on You (2003) as April Mercedes
* Bewitched (2005) as Isabel Bigelow / Samantha Stephens
* The Big Wedding (2013) as Lyla Griffin
Television:
* Friends (1994-1995) as Ursula Buffay
* Mad About You (1995) as Paige Chase
* Frasier (1996) as Daphne Moon
* Suddenly Susan (1996-1997) as Susan Keane
* Just Shoot Me! (1997-2003) as Maya Gallo
* Will & Grace (1998-2006) as Karen Walker
* Web Therapy (2011-2015) as Fiona Wallace
* BoJack Horseman (2014-2020) as Princess Carolyn
* American Crime Story: The People v. O.J. Simpson (2016) as Kris Jenner
* The Politician (2019-2020) as Georgina Hobart