- Fox Ranch, Malibu, California: This 2,000-acre ranch served as the primary location for the series, and it was where the majority of the outdoor scenes were filmed. The production crew built sets on the ranch, including the 4077th Mobile Army Surgical Hospital, the Swamp, and other military installations.
- 20th Century Fox Studios, Century City, California: The studio facilities at 20th Century Fox Studios were used for filming interior scenes, such as the hospital wards, operating rooms, and the Officers' Club. Soundstages were utilized to create these sets, allowing for greater control over lighting, sound, and other technical aspects.
Some additional scenes were also filmed in other locations, such as the Santa Monica Mountains and the Mojave Desert, to provide a variety of natural settings and landscapes.