Film:
* The House Bunny (2008) as Shelley
* The Informant! (2009) as Janine
* The Good Guy (2009) as Jill
* Happy Feet Two (2011) as Norma Jean (voice)
* The Big Year (2011) as Ellie
* The Interview (2014) as Sook
* The Overnight (2015) as Kathryn
* The Wedding Ringer (2015) as Nadine
* The Last Word (2017) as Anne
* The Unicorn (2019) as Carolyn
Television:
* Dawson's Creek (2003) as Emma
* Six Feet Under (2003-2005) as Brenda Chenowith
* Everwood (2004) as Maggie
* Life as We Know It (2004-2005) as Katie
* The O.C. (2005) as Ava
* CSI: Crime Scene Investigation (2006) as Bethany
* Grey's Anatomy (2006) as Sarah
* Eli Stone (2008-2009) as Katie
* 90210 (2008-2009) as Naomi Clark
* Gossip Girl (2009) as Serena van der Woodsen
* The Good Wife (2011) as Samantha
* Private Practice (2011-2013) as Dr. Violet Ford
* Scandal (2014-2015) as Abby Whelan
* The Good Place (2016) as Eleanor Shellstrop
* The Kominsky Method (2018-2021) as Lisa
* The Afterparty (2022) as Detective Danner
This is not an exhaustive list, but it showcases the breadth of Sarah Thompson's work in film and television.