Television
* Bones (2005-2017): As Dr. Jack Hodgins, a forensic entomologist and an integral member of the Jeffersonian team. This is his most prominent role.
* The Mentalist (2012): As Dr. Jack Hodgins, in a crossover episode with "Bones."
* The Last Man On Earth (2015-2018): As Todd, a character in the post-apocalyptic comedy series.
* American Dad! (2016): As a voice role in the animated series.
* The Goldbergs (2018): As a guest star in the sitcom.
* Young Sheldon (2018): As a guest star in the prequel to "The Big Bang Theory."
* Superstore (2019): As a guest star in the comedy series.
* Star Trek: Picard (2023): As Dr. Altan Inigo Soong, a character in the "Star Trek" series.
Movies
* The Girl Next Door (2004): As a young man, this was one of his early film roles.
* Superman: Brainiac Attacks (2006): As a voice role for the animated film.
* The Dukes of Hazzard (2005): As a character in the action comedy film.
* The Last Man On Earth: The Complete Series (2015-2018): A compilation of the series he was in.
* The Emoji Movie (2017): As a voice role in the animated film.
This is not an exhaustive list, but it covers most of his notable projects. TJ Thyne is known for his comedic timing and his ability to play a variety of characters.