Film:
* The Manchurian Candidate (2004): Played Senator John "Johnny" Iselin
* The Contender (2000): Played the role of Chief of Staff, Fred Benning
* The Insider (1999): Played the role of Lowell Bergman's lawyer
* Nixon (1995): Played the role of Jeb Magruder
* JFK (1991): Played the role of Jack C. "Jack" Clements
* The Trial of the Chicago 7 (2020): Played the role of Judge Julius Hoffman
* The Post (2017): Played the role of General Graham Martin
* The Informant! (2009): Played the role of David "Dave" Armstrong
* The Sum of All Fears (2002): Played the role of Gen. Jim Ritter
* The Pelican Brief (1993): Played the role of Gray Grantham
* The Firm (1993): Played the role of Avery Tolar
* The Doctor (1991): Played the role of Dr. Dan Keegan
* The Hunt for Red October (1990): Played the role of Capt. Bart Mancuso
Television:
* House of Cards (2013-2018): Played the role of Raymond Tusk
* The Good Wife (2011-2016): Played the role of Peter Florrick
* The Americans (2013-2018): Played the role of William
* The Knick (2014-2015): Played the role of Dr. Herman Rochester
* The West Wing (1999-2006): Played the role of Leo McGarry
* Law & Order: Special Victims Unit (2012): Played the role of Richard Haines
* Law & Order: Criminal Intent (2007): Played the role of Lawrence Schaeffer
* Oz (1997-2003): Played the role of Tim McManus
* The Wire (2002-2008): Played the role of Mayor Clarence Royce
* Homicide: Life on the Street (1993-1999): Played the role of Det. Don Madigan
* The Sopranos (2000-2007): Played the role of Agent Harris
This is just a partial list of Larry Pine's extensive filmography. He has also appeared in numerous other films, television shows, and stage productions throughout his career.