Television
* The Simpsons (1989-present): Homer Simpson, Krusty the Clown, Barney Gumble, Mayor Quimby, Groundskeeper Willie, and many other characters.
* The Critic (1994-1995): The voice of various characters, including the main character, Jay Sherman.
* The Cleveland Show (2009-2013): Voice of "Mr. Weasle" in the episode "The Curious Case of Benjamin Button."
* The Tracey Ullman Show (1987-1990): The voice of various characters in the original *Simpsons* shorts.
* The Adventures of Jimmy Neutron: Boy Genius (2002-2006): Voice of "Carl Wheezer."
* The Powerpuff Girls (1998-2005): Voice of "Fuzzy Lumpkins."
* SpongeBob SquarePants (1999-present): Voice of "Larry the Lobster."
* Family Guy (1999-present): Voice of "Herbert."
* American Dad! (2005-present): Voice of "Stan Smith."
* King of the Hill (1997-2009): Voice of various characters, including "Hank Hill" in a few episodes.
* Futurama (1999-2003, 2008-2013): Voice of various characters.
Movies
* The Simpsons Movie (2007): Homer Simpson, Krusty the Clown, Barney Gumble, and Mayor Quimby.
* The Brave Little Toaster Goes to Mars (1998): The voice of the "Toaster."
* The Simpsons Ride (2008): Homer Simpson, Krusty the Clown, Barney Gumble, and Mayor Quimby.
* The Peanuts Movie (2015): Voice of "Snoopy."
* Toy Story 4 (2019): Voice of "Forky."
* Onward (2020): Voice of "The Manticore."
This list is not exhaustive but includes some of the most prominent and notable projects Dan Castellaneta has been involved in. He has lent his voice to countless other animated productions and even had a few live-action roles.