Movies:
* "Fast Times at Ridgemont High" (1982): Their song "Keep on Loving You" is featured prominently in the movie's soundtrack and a scene where the characters attend a school dance.
* "The Breakfast Club" (1985): "Roll With the Changes" plays in a scene where the students are released from detention.
Television:
* "The Simpsons" (1991): They are featured in the episode "The Last Temptation of Krusty" where they perform their song "Can't Fight This Feeling" and are also drawn into the show's animation style.
* "South Park" (2000): In the episode "Chef Aid" (a parody of "Live Aid"), they appear in the "South Park" animation style along with other bands and artists like R.E.M. and Elton John.
* "The King of Queens" (2000): Their song "Take It On the Run" is used in the episode "The Big Sleep" which features a scene where the character Doug Heffernan dreams he's in a REO Speedwagon music video.
* "Family Guy" (2001): The band's song "Keep on Loving You" is featured in the episode "Road to Europe."
* "Scrubs" (2002): The song "Time for Me to Fly" plays during the episode "My Best Friend's Wife."
* "The Office" (2006): The song "Roll With the Changes" plays during the episode "The Client."
* "Glee" (2010): The band's song "Can't Fight This Feeling" is performed in the episode "The Power of Madonna."
Note: This list may not be exhaustive as some smaller appearances or uses of their music in various media may not be readily available.