Movies:
* Pee-wee's Big Adventure (1985) - His breakout role as the lovable and eccentric Pee-wee Herman
* The Pee-wee Herman Show on HBO (1981-1985) - The original HBO series that launched his career
* Big Top Pee-wee (1988) - Pee-wee's second film
* Batman Returns (1992) - As the Penguin's henchman, "The Penguin's"
* Mystery Men (1999) - As the superhero, "The Spleen"
* Blow (2001) - As "Derek"
* The Longest Yard (2005) - As "Caretaker"
* Life During Wartime (2009) - As "The Man"
* The Blacklist (2013-2017) - As "The Major"
* Pee-wee's Big Holiday (2016) - Returning as Pee-wee Herman in this Netflix film
Television:
* The Pee-wee Herman Show (1981-1985) - Original HBO series
* Pee-wee's Playhouse (1986-1990) - His iconic children's show on CBS
* The Amazing Live Sea-Monkeys (1989) - A made-for-television movie
* The Larry Sanders Show (1992-1998) - In recurring roles
* Murphy Brown (1988-1998) - In recurring roles
* 30 Rock (2006-2013) - In recurring roles
* The Blacklist (2013-2017) - As "The Major"
* The Simpsons (2013) - As himself in a guest appearance
* BoJack Horseman (2014-2020) - As "Mr. Peanutbutter"
* Disenchantment (2018-present) - As "Elfo"
* The Mandalorian (2019-present) - As "The Mythrol" in season 1
This is not an exhaustive list, but it captures some of his most well-known roles in film and television. Paul Reubens is known for his unique comedic talent, often performing in outlandish characters and costumes. His career continues to thrive, and he continues to delight audiences with his work.