Television
* "The 100" (2014-2020) as Marcus Kane
* "Nikita" (2010-2013) as Michael
* "Smallville" (2001-2011) as Ethan
* "The L Word" (2004-2009) as Shane
* "Blue Mountain State" (2010-2011) as Coach
* "The Art of More" (2015-2016) as Arthur Davenport
* "The Magicians" (2016-2020) as Eliot Waugh
* "The Flash" (2014-present) as Henry Allen (voice)
* "Supergirl" (2015-2021) as Henry Allen (voice)
Films
* "The Twilight Saga: Breaking Dawn - Part 1" (2011) as Jacob's Imprint
* "The Twilight Saga: Breaking Dawn - Part 2" (2012) as Jacob's Imprint
* "The Day" (2011) as Josh
* "The Truth About Angels" (2009) as Michael
* "The Game" (2012) as Paul
* "Girl in Progress" (2012) as Rick
* "The Last Airbender" (2010) as Fire Nation Soldier
* "The Scorpion King 4: Quest for Power" (2012) as Talus
* "The Scorpion King: Battle for Redemption" (2015) as Talus
* "The Order" (2019) as The Warden
* "The Devil's Light" (2022) as Father Ben
This list is not exhaustive, but it highlights some of Patrick Cupo's most recognizable roles. He has been a versatile actor throughout his career, taking on a variety of characters in different genres.