Film:
* Band of Brothers (2001) - Sgt. Carwood Lipton
* The Taking of Pelham 1 2 3 (2009) - Garcia
* The A-Team (2010) - Hector "The Hammer" Ramirez
* The Twilight Saga: Breaking Dawn – Part 2 (2012) - Dr. Royce
* The Last Ship (2014) - Lt. Commander Danny Green
* American Made (2017) - Barry Seal's partner
* The Irishman (2019) - Frank Sheeran's Lawyer
* The Suicide Squad (2021) - General Mateo Suarez
Television:
* Oz (1997-2003) - Miguel Alvarez
* Law & Order: Special Victims Unit (2000-2018) - Multiple roles
* 100 Centre Street (2001-2002) - Detective Rey Curtis
* The Shield (2002-2008) - Detective "Lem" Lemansky
* Fringe (2010-2013) - Agent "Charlie" Francis
* Zero Hour (2013) - Dr. Arden Crane
* The Walking Dead (2015) - Dr. Eugene Porter
* Prison Break (2017) - Agent Soto
* The Sinner (2017-2018) - Detective Harry Ambrose
* Blindspot (2015-2020) - Agent Rich Dotcom
* The Expanse (2015-2022) - Josep "Joe" Miller
* Cowboy Ninja Viking (2019) - Agent "D" Dunn
* Star Trek: Picard (2020-2023) - Dr. Altan Inigo Soong
This is not an exhaustive list, but it highlights some of his most notable works. Kirk Acevedo has demonstrated a versatility that allows him to play diverse roles, making him a respected and sought-after actor in Hollywood.