Movies
* Detective Story (1951) - Her film debut, earning her an Academy Award nomination for Best Supporting Actress.
* The Cobweb (1955)
* The Heartbreak Kid (1972) - Nominated for an Academy Award for Best Supporting Actress.
* Shampoo (1975) - Won the Academy Award for Best Supporting Actress.
* Voyage of the Damned (1976)
* The Front (1976) - Nominated for an Academy Award for Best Actress.
* The Big Fix (1978)
* The Verdict (1982)
* The Lonely Lady (1983)
* The Money Pit (1986)
* The Milagro Beanfield War (1988)
* The Prince of Tides (1991)
* The Player (1992)
* The Age of Innocence (1993)
* The Mirror Has Two Faces (1996)
* The Impostors (1998)
* The House of Mirth (2000)
* The Family Stone (2005)
Television
* Studio One (1948-1958) - Numerous appearances in this iconic television anthology series.
* The Philco Television Playhouse (1948-1955)
* The Twilight Zone (1960) - Appeared in the episode "The Mind and the Matter."
* The Defenders (1961-1965) - Appeared in several episodes.
* The Alfred Hitchcock Hour (1962-1965)
* The Nurses (1962-1965)
* The Fugitive (1963-1967) - Appeared in the episode "The Savage"
* The Patty Duke Show (1963-1966)
* The Trials of O'Brien (1965)
* The Wild Wild West (1965-1969)
* The Name of the Game (1968-1971)
* Columbo (1971-2003) - Appeared in the episode "Double Shock."
* The Rockford Files (1974-1980)
* The Love Boat (1977-1986) - Appeared in several episodes.
* Murder, She Wrote (1984-1996) - Appeared in the episode "Murder Takes the Case."
* Law & Order (1990-2010) - Appeared in the episode "The Serpent."
* ER (1994-2009)
* Desperate Housewives (2004-2012)
* Ugly Betty (2006-2010)
This list is by no means exhaustive, but it highlights some of Lee Grant's most memorable and critically acclaimed roles in both film and television. She was known for her versatility and her ability to portray complex, often flawed characters with great depth and nuance.