Movies:
* The Maze Runner (2014) - Minho
* Ride Along (2014) - Bz
* The Maze Runner: Scorch Trials (2015) - Minho
* The Maze Runner: The Death Cure (2018) - Minho
* Sleight (2016) - Bo
* Detroit (2017) - Lee
* The Last Summer (2019) - Tyler
* The Weekend (2018) - Greg
* Grown Ups (2010) - Young Andy
* Black Nativity (2013) - Langston
* The Perfect Match (2016) - Daniel
* The Trap (2017) - D
* Collateral Beauty (2016) - Bryce
* Extracurricular Activities (2015) - Jacob
* Starlight (2020) - Mike
* The Little Things (2021) - Kenny
* The Tender Bar (2021) - Richie
* A Madea Homecoming (2022) - Tim
* The Woman King (2022) - Malik
Television:
* The Wire (2008) - Day-Day
* The Wire (2006) - Young Day-Day (voice)
* Meet the Browns (2009) - Malik
* One Tree Hill (2011) - Cameron
* The Red Road (2014) - Harold
* Survivor's Remorse (2014-2017) - Cam Calloway
* The Oath (2018) - Tariq "T" Cole
* The Chi (2018-2022) - Coolio
* Black Monday (2019) - Dwayne
* The Umbrella Academy (2020) - Marcus
* The Last Ship (2014-2018) - Donnie
* House of Cards (2016) - Corey
* Being Mary Jane (2015) - Andre
* The Resident (2018) - Devon Pravesh
* The Rookie (2018) - Jackson West
* Outer Banks (2020) - Pope
This list may not be exhaustive, but it includes most of Jacob Latimore's major film and television roles. He has also appeared in various music videos and short films.