Movies:
* L'amore molesto (The Troubling Love, 1995): This film by Mario Martone marked a turning point in Calzone's career, earning her a David di Donatello Award for Best Supporting Actress.
* Ferdinando and Carolina (1999): Calzone played the title character of Queen Carolina in this historical drama by Lina Wertmüller.
* La meglio gioventù (The Best of Youth, 2003): This critically acclaimed film by Marco Tullio Giordana features Calzone as Giulia, a key character in the story spanning decades.
* Il Caimano (2006): Calzone portrayed the role of a journalist in this political satire by Nanni Moretti.
* La vita che volevo (The Life I Wanted, 2010): This film by Fabio Cavalli features Calzone in a leading role.
* Perez. (2014): This comedy-drama film by Eduardo De Angelis showcases Calzone in a supporting role.
* Napoli Velata (2016): Calzone played the character of Maria in this film directed by Ferzan Özpetek.
Television:
* Un medico in famiglia (A Doctor in the Family, 1998-present): Calzone is most famous for her portrayal of the character of "Nonna Libera" in this long-running Italian television series.
* La porta rossa (The Red Door, 2017-present): Calzone played the role of the character "Anna" in this television series.
* L'amica geniale (My Brilliant Friend, 2018-present): Calzone played the role of "Nunzia" in this critically acclaimed television series based on Elena Ferrante's novels.
This list is not exhaustive, but it encompasses some of the most significant film and television projects Maria Pia Calzone has been involved in.