- Academy Awards:
- Best Supporting Actress for "Ghost" (1991)
- Golden Globe Awards:
- Best Supporting Actress – Motion Picture for "Ghost" (1991)
- Best Actress – Television Series Musical or Comedy for "The Whoopi Goldberg Show" (1989)
- BAFTA Awards:
- Best Supporting Actress for "Ghost" (1991)
- Emmy Awards:
- Outstanding Talk Show Host for "The View" (2009 and 2011)
- Grammy Awards:
- Best Comedy Album for "Whoopi Goldberg: Original Broadway Show Recording" (1985)
- People's Choice Awards:
- Favorite All-Around Female Performer (1988 and 1991)
- Favorite Female Performer in a New TV Series for "The Whoopi Goldberg Show" (1988)
- Favorite Female TV Performer (1989 and 1991)
- MTV Movie Awards:
- Best Comedic Performance for "Sister Act" (1993)
- National Association for the Advancement of Colored People (NAACP) Image Awards:
- Outstanding Supporting Actress in a Motion Picture for "Ghost" (1991)
- Outstanding Variety Series – Music/Variety for "The Whoopi Goldberg Show" (1989)
- Entertainer of the Year (1990)
- Tony Awards:
- Special Award for Outstanding Achievement in the Theatre (2002)
- American Comedy Awards:
- Funniest Female Performer in a Leading Role in a Motion Picture for "Ghost" (1991)
- Saturn Awards:
- Best Supporting Actress for "Ghost" (1991)
- ShoWest Convention Awards:
- Female Star of the Year (1991)