It's possible you're thinking of:
* "The Nanny" (1993-1999): Fran Drescher starred in this popular sitcom, but there is no mention of a 2010 spin-off or sequel.
* "Happily Divorced" (2012-2013): This sitcom starring Fran Drescher aired on TV Land and is about a couple who decides to divorce after 20 years, but then discover they are both happier as singles.
Please clarify your question if you can provide more information about the show you're looking for.