1. Enter the "Cheat Menu" by pressing the Start button and selecting the "Extras" option.
2. Select the "Cheats" option.
3. Input the following cheat code using the controller buttons or analog stick: Up, Up, Down, Down, Left, Right, Left, Right, X, Circle.
4. A "Cheat Activated" message will appear on the screen.
Once the cheat is activated, Spider-Man will become invincible and immune to all damage. However, this cheat will disable achievements and trophies, so use it wisely. To turn off the cheat, simply repeat the steps above.