* Justin Russo: Alex's older brother, Justin is a responsible and intelligent wizard who is often the voice of reason in the family.
* Max Russo: Alex and Justin's younger brother, Max is a mischievous and often clueless wizard who is often the cause of the family's problems.
* Theresa Russo: Alex, Justin, and Max's mother, Theresa is a former wizard who gave up her powers to marry Alex's father.
* Jerry Russo: Alex, Justin, and Max's father, Jerry is a former wizard who now owns and operates a sandwich shop.
* Harper Finkle: Alex's best friend, Harper is a non-magical mortal who is often caught up in the Russo family's magical adventures.
* Zeke Beakerman: Justin's best friend, Zeke is a non-magical mortal who is also often caught up in the Russo family's magical adventures.
* Dean Moriarty: Alex's boyfriend, Dean is a werewolf who is often at odds with the Russo family.
* Juliet Van Heusen: Alex's rival, Juliet is a powerful wizard who is often trying to steal Alex's powers.
* Hugh Normous: The headmaster of WizTech, Hugh Normous is a powerful wizard who is often trying to keep Alex in line.