* Stand-up comedy: He is recognized as a successful stand-up comedian with a distinctive style characterized by his high-energy, physical humor, and offbeat observations.
* Television: He has hosted numerous popular television shows, including:
* Deal or No Deal: His most well-known hosting gig, running from 2005 to 2009, where he was known for his energetic and unpredictable demeanor.
* America's Got Talent: He served as a judge on this popular talent show from 2010 to 2020, providing his unique commentary and humor.
* Mobbed: He hosted this reality show from 2013 to 2015, which featured surprise reunions and heartwarming moments.
* Acting: He has appeared in numerous film and television roles, including:
* St. Elsewhere: One of his early roles, playing Dr. Wayne Fiscus, a young, quirky doctor on the critically acclaimed medical drama.
* Bobby's World: He provided the voice of the main character in this animated series, which aired from 1990 to 1998.
* Gremlins: He starred as Gizmo's owner, Randall Peltzer, in the cult classic film.
Mandel is known for his outspoken personality, his signature catchphrase "Ohhh," and his humor, which often revolves around his personal experiences and observations on life. He is a respected figure in the entertainment industry and continues to be active in both television and stand-up comedy.