Can a PSP disk work on PS2?

No, a PSP (PlayStation Portable) disk will not work on a PS2 (PlayStation 2) console. These two gaming systems use different types of media and are not compatible with each other. PSP disks are UMD (Universal Media Disc) format, while PS2 disks are DVD-ROM (Digital Versatile Disc-Read-Only Memory) format. Additionally, the software and hardware of the PSP and PS2 are not compatible, meaning that even if you could insert a PSP disk into a PS2, it would not be able to read or play the game.