Escape plans: The escape plans in Prison Break are often very elaborate and require a great deal of planning and coordination. In reality, most prison escapes are much simpler and involve taking advantage of a security weakness or bribing a guard.
Security measures: The security measures at the prison in Prison Break are very lax. For example, there are no cameras in the cells, and the guards are often not very attentive. In reality, maximum-security prisons have much tighter security, making it very difficult to escape.
Character skills: The characters in Prison Break are all very skilled and capable. They are able to fight, climb walls, and pick locks. In reality, most prisoners are not as skilled as the characters in Prison Break, making it less likely that they would be able to escape.
Overall: Prison Break is a fun and entertaining show, but it is not very realistic. The escape plans are too elaborate, the security measures are too lax, and the characters are too skilled. In reality, most prison escapes are much simpler and less successful.