Films:
* The Santa Clause 2 (2002): Mrs. Claus
* The Santa Clause 3: The Escape Clause (2006): Mrs. Claus
* The Wedding Singer (1998): Linda
* 27 Dresses (2008): Aunt Marge
* Bad Teacher (2011): Mrs. Rizzoli
* The Guilt Trip (2012): Barbara
* The Heat (2013): Mrs. Keegan
* The Other Woman (2014): Doris
* The Intern (2015): Mrs. Flowers
* The Boss (2016): Gail
* A Bad Moms Christmas (2017): Ruth
* Life of the Party (2018): Professor Donna
* Instant Family (2018): Margaret
Television:
* The King of Queens (2000-2007): Debbie (recurring role)
* According to Jim (2001-2009): Barb (recurring role)
* Desperate Housewives (2004-2012): Mrs. McClusky (recurring role)
* The Middle (2009-2018): Ethel (recurring role)
* Grey's Anatomy (2005-2018): various roles (recurring role)
* Two and a Half Men (2003-2015): various roles (recurring role)
* Modern Family (2009-2020): various roles (recurring role)
* The Good Wife (2009-2016): various roles (recurring role)
* Superstore (2015-2021): various roles (recurring role)
* Mom (2013-2021): various roles (recurring role)
This list is not exhaustive, but it highlights some of Mary Pat Gleason's most memorable and iconic roles.
Note: Mary Pat Gleason sadly passed away in 2018. She will be remembered for her comedic timing, her ability to bring warmth and heart to her characters, and her contribution to the world of entertainment.