* John Douglas: The main protagonist, who is also known as "The Professor" and "The Man with the Twisted Lip," is killed by McMurdo.
* McMurdo: The main antagonist, who is a member of the "Scowrers," is killed by John Douglas.
* Ethel Hudson: John Douglas's love interest, is kidnapped and murdered by McMurdo.
* Edward (Ted) Hudson: Ethel's father, is killed by McMurdo.
* Jack McMurdo: McMurdo's son, is murdered by the "Scowrers" (presumably) as part of a plot to ensure silence about their activities.
There are other deaths mentioned in the novel, including those of several "Scowrers," but these are the most prominent.