Go through the "New York Times" and "Business Week" best-seller list. Read reviews given by book critics to better understand the market and audience. Understand what kind of topics and concepts are identified as a best-seller by the media.
Learn from other best-selling authors of your genre by reading their interviews and marketing styles. Unique talent is the basis for a good book but a strategic business approach is essential to make it a best-seller.
Open the story with a strong hook, which holds the reader's attention and motivates them to read further. Readers care about how real the characters are. So focus on individualizing the characters more than plot or situations to captivate the readers and make it a best-seller.
Place cliffhangers at the end of each chapter to sustain the curiosity of the reader. The more readers talk about your book, the more likely it is to increase the sales and land your book in the best-seller spot.
Promote your book using the right reviewers. Publicize your book by setting up appearances in bookstores and libraries, arranging book talks and signings, printing press releases through newspapers and magazines and developing a marketing kit through an independent publicist.