* _If Morning Ever Comes_ (1964)
* _The Tin Can Tree_ (1965)
* _A Slipping-Down Life_ (1970)
* _The Clock Winder_ (1972)
* _Celestial Navigation_ (1974)
* _Searching for Caleb_ (1975)
* _Earthly Possessions_ (1977)
* _Morgan's Passing_ (1980)
* _Dinner at the Homesick Restaurant_ (1982)
* _The Accidental Tourist_ (1985)
* _Breathing Lessons_ (1988)
* _Saint Maybe_ (1991)
* _Ladder of Years_ (1995)
* _A Patchwork Planet_ (1998)
* _Back When We Were Grownups_ (2001)
* _The Amateur Marriage_ (2004)
* _Digging to America_ (2006)
* _Noah's Compass_ (2010)
* _The Beginner's Goodbye_ (2012)
* _Redhead by the Side of the Road_ (2013)
* _Vinegar Girl_ (2016)
Short story collections
* _The Artificial Family_ (1974)
* _Natural Wonders_ (1985)
* _Breathing Lessons: And Other Stories_ (1988)
* _The Best American Short Stories of 1989_ (edited by Anne Tyler) (1989)
* _At the Agile Angler_ (2004)
Non-fiction
* _The Art of Fiction_ (2017)
Children's books
* _Timothy and the Strong Coffee_ (1983)
* _Tumble Tower_ (1985)
* _The Grannyman_ (1987)