He is considered one of the most important muralists of the 20th century and is known for his large-scale, vibrant, and often politically charged murals.
Some of his most famous works include:
* The Detroit Industry Murals (Detroit Institute of Arts)
* The History of Mexico (National Palace, Mexico City)
* The Man at the Crossroads (Rockefeller Center, New York City - later destroyed)
Other notable Mexican muralists include:
* José Clemente Orozco
* David Alfaro Siqueiros
* Rufino Tamayo