Leatherworking uses a variety of materials and reagents, but Elixir of Defense is not one of them. It's used by players to increase their armor rating, which boosts their defensive capabilities.
Here's what you likely need to know about leatherworking:
* Materials: Leatherworking uses various materials, including hides, leather scraps, and other reagents like thread and gems.
* Recipes: To craft leatherworking items, you'll need to learn recipes from trainers or find them as loot.
* Crafting: Once you have the necessary materials and recipes, you can craft leatherworking items at a tanning rack.
If you're looking for a specific recipe for a leatherworking item, please tell me what it is, and I can help you find where to get it.